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2019 - 09 - 29
2019年8月24日訊 /生物谷BIOON /——一項新的研究表明,一種特殊的碳水化合物在調節人體血壓方面發揮著重要作用。哥本哈根大學和Rigshospitalet的研究人員用老鼠做了一項新的研究證明了這一點。研究人員認為,這一發現可能對改進高血壓藥物具有巨大的潛力。高血壓和低血壓都可能對健康產生不良后果,分別導致心血管疾病和暈厥?,F在,研究人員對有助于調節血壓的因素有了更多的了解。這項新研究結果發表在《Journal of Biological Chemistry》雜志上。在哥本哈根大學和Rigshospitalet的跨學科合作中,博士生Lasse Holst Hansen在人類身上一種特殊的肽激素上發現了一種特定形式的碳水化合物或糖。此外,在對大鼠的實驗中,研究小組發現含有這種糖的肽激素會影響血壓的調節。他們希望,他們的研究結果在未來可以用于開發更好的高血壓藥物。圖片來源:https://cn.bing.com'對于開發一種沒有副作用(比如暈厥)的現代治療高血壓的方法,這可能是一個非常好的機會。人們早就知道這種肽激素對血壓非常重要,但到目前為止還不能用于治療。這一發現可能只是因為我們跨學科合作、基礎和臨床研究相結合的結果。'Rigshospitalet臨床生物化學系Jens Peter G?tze教授說道。大約五分之一的丹麥人患有高血壓。這會增加心血管疾病的風險,如冠狀動脈血栓...
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2019 - 06 - 18
和50年前相比,現在人們日??防飻z入更多,平均每天高出650大卡,相當于每天多吃了一頓有漢堡、薯條和可樂的套餐,約占男性和女性每日所需食物能量的1/4和1/3。這些多余的卡路里不僅體現在越來越多人圓滾的腰圍上,根據澳大利亞國立大學(Australian National University,ANU)的專家提醒,更會對我們的大腦帶來“毀滅性”的影響。ANU團隊的最新研究顯示,由于不健康生活方式,大腦功能衰退可能比我們想象得更早。研究結果近日發表在Frontiers in Neuroendocrinology。根據世界衛生組織的數據,全球約有39%的成人超重,13%的成人肥胖。作為超重和肥胖的常見健康后果之一,2型糖尿病在2030年將影響約10%的成人。眾所周知,2型糖尿病與大腦健康受損、認知功能退化有關,神經損傷也是糖尿病的并發癥之一。那么,在還沒有出現高血糖等符合糖尿病診斷的癥狀時,神經退行性病變和認知障礙是否也已經處于病理過程中了?又與哪些導致血糖變化的因素有關?研究團隊回顧了近200項相關的國際研究,結果表明,即便是非糖尿病人群,由于血糖偏高和肥胖而導致的神經病變也在非常早期就開始了,并且從那時起就開始影響大腦健康和認知功能。比如,一項涉及澳大利亞超過7000人的PATH研究顯示,哪怕血糖值尚且在正常范圍內,但血糖偏高的人群,大腦中海馬和杏仁核普遍萎縮更多,4年內體積約縮小...
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2019 - 06 - 14
隨著技術飛速發展、醫學數據的持續擴增以及硬件設備的不斷提升,人工智能和醫療的結合方式越來越多樣化。目前AI在醫療領域中的落地的應用場景主要有醫學影像、智能診療、智能導診、智能語音、健康管理、病例分析、醫院管理、新藥研發和醫療機器人等,其中在醫學影像中的應用最為廣泛。一、影像醫學發展現狀醫學影像是醫生完成診斷的主要依據,通過對影像的分析和比較,從而完成有依據的診斷。但是在實際過程中,往往會存在以下問題:(1)影像學診斷人才資源緊缺。醫療機構普遍缺乏高水平的影像醫師,在疾病診斷時往往會發生同病異影,異病同影等情況。(2)傳統定性分析存在診斷誤差。醫生普遍擅長定性分析,很多微小的定量變化無法通過肉眼判斷,很難做到定量分析。(3)醫生閱片時間長。目前的影像呈現方式為數據和圖像,而不是最有效的信息,很大程度上限制了醫生的人工閱片速度。二、AI+醫學影像助力疾病診斷通過引入人工智能可有效解決部分問題,目前人工智能在醫學影像領域的應用方向主要以下幾類:1. 影像設備的圖像重建AI可以通過算法的圖像映射技術,將采集的少量信號恢復出與全采樣圖像同樣質量的圖像,而且使用圖像重建技術,可以由低劑量的CT和PET圖像重建得到高劑量質量圖像。這樣在滿足臨床診斷需求的同時,還能夠降低輻射的風險。2. 智能輔助診斷疾?。?)智能輔助診斷肺部疾病國內應用AI+CT影像最為成熟的領域在肺結節的識別上。AI能夠有效識...
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時間: 2019 - 04 - 22
描述The LIVE/DEAD? Fixable Green Dead Cell Stain Kit is used to determine the viability of cells prior to the fixation and permeabilization required for intracellular antibody staining or prior to elimination of biohazardous materials using formaldehyde fixation. This kit has been optimized and validated for use with a blue laser flow cytometer.? Stable—dyes are freeze dried in separate vials to maintain stability? Robust—staining pattern is the same before and after fixation? Bright signal—allows...
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時間: 2019 - 04 - 18
描述This product detects the externalization of phosphatidylserine in apoptotic cells using recombinant annexin V conjugated to green-fluorescent FITC dye and dead cells using propidium iodide (PI). Propidium iodide stains necrotic cells with red fluorescence. After treatment with both probes, apoptotic cells show green fluorescence, dead cells show red and green fluorescence, and live cells show little or no fluorescence.
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時間: 2019 - 04 - 18
描述SYTOX® Green nucleic acid stain is an excellent green-fluorescent nuclear and chromosome counterstain that is impermeant to live cells, making it a useful indicator of dead cells within a population.?  Impermeant to live cells?  Excitation/Emission: 504/523 nm?  Use with 488 Argon-ion laser?  Works with mammalian cells and both Gram-positive and Gram-negative bacteriaSimple Viability Determination SYTOX® Green allows quick determination of cell viability when usin...
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時間: 2019 - 04 - 18
描述Premo? FUCCI Cell Cycle Sensor is a fluorescent, two-color sensor of cell cycle progression and division in live cells. It allows accurate and sensitive cell cycle analysis of individual cells or a population of cells by fluorescence microscopy, flow cytometry, or high-content imaging.At 2 x 200 µL, this is a smaller pack size version (1/5 volume) of the popular full-size product and perfect for testing its performance in your system.The Premo? FUCCI Cell Cycle Sensor is delivered by high...
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時間: 2019 - 04 - 18
描述CountBright? absolute counting beads are a calibrated suspension of microspheres that are brightly fluorescent across a wide range of excitation and emission wavelengths (UV to 635 nm excitation and 385-800 nm emission). CountBright? absolute counting beads are mixed with the cell sample and assayed via flow cytometry. By comparing the ratio of bead events to cell events, absolute numbers of cells in the sample can be calculated. Because CountBright? beads are mixed in the test sample, absolut...
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時間: 2019 - 04 - 17
描述CellTrace? CFSE Cell Proliferation Kit is used for in vitro and in vivo labeling of cells to trace multiple generations using dye dilution by flow cytometry.? Superior performance—bright, single-peak staining enables visualization of multiple generations? Long-term signal stability—well-retained in cells for several days post stain? Non-toxic—staining does not adversely effect cell health? Simple, robust staining protocolView a selection guide for all CellTrace? Cell Proliferation Kits fo...
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時間: 2019 - 04 - 17
描述CellTrace? CFSE 細胞增殖試劑盒 (CellTrace? CFSE Cell Proliferation Kit) 以方便的一次性瓶裝形式提供用途廣泛,穩定性高的細胞示蹤劑。 羧基熒光素二醋酸鹽琥珀酰亞胺酯,常稱為 CFSE,可被動擴散進入細胞。 這種試劑沒有顏色和熒光,直至細胞內的酯酶去除其醋酸鹽基團,產生能發出明亮熒光的羧基熒光素琥珀酰亞胺酯。 琥珀酰亞胺酯與細胞內氨基反應,形成穩定且能用醛固定劑固定的熒光偶聯物。 此試劑盒包含十份一次性瓶裝的 CFSE,因此進行小規模實驗時無需制備過量的易變質 CFSE 儲存液。 此試劑盒還包括高質量的 DMSO(二甲基亞砜)和詳細的實驗方案。For Research Use Only. Not for use in diagnostic procedures.圖表Suppressive capacity of isolated Treg cells.Suppressive capacity of isolated Treg cells. (A) CD4+ CD25–cells were stained with Ca...
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時間: 2019 - 04 - 17
描述The Click-iT® EdU Pacific Blue? Flow Cytometry Assay Kit provides a simplified, more robust assay for analyzing DNA replication in proliferating cells as compared to traditional BrdU methods. Newly synthesized DNA is analyzed using the 405 nm laser of the flow cytometer.? Accurate—superior results compared to BrdU assays? Fast—results in as little as 90 minutes? Economical—more assays per kitView selection guide for all Click-iT? EdU and Click-iT? Plus EdU assays for flow c...
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時間: 2019 - 04 - 17
描述The 2018 Attune NxT Acoustic Focusing Cytometer has expanded functionalities to drive your research forward. Designed and developed to remove common barriers associated with flow cytometry, the evolutionary capabilities of the Attune NxT flow cytometer offer adaptable optical configuration options so you can get the most out of your multicolor analysis.? Free Attune NxT software with researcher-inspired upgrades? New green laser option for expanded utility and fluorochrome options? Simple push...
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時間: 2019 - 04 - 17
描述The 2018 Attune NxT Acoustic Focusing Cytometer has expanded functionalities to drive your research forward. Designed and developed to remove common barriers associated with flow cytometry, the evolutionary capabilities of the Attune NxT flow cytometer offer adaptable optical configuration options so you can get the most out of your multicolor analysis.? Free Attune NxT software with researcher-inspired upgrades? New green laser option for expanded utility and fluorochrome options? Simple push...
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時間: 2019 - 04 - 17
描述The 2018 Attune NxT Acoustic Focusing Cytometer has expanded functionalities to drive your research forward. Designed and developed to remove common barriers associated with flow cytometry, the evolutionary capabilities of the Attune NxT flow cytometer offer adaptable optical configuration options so you can get the most out of your multicolor analysis.? Free Attune NxT software with researcher-inspired upgrades? New green laser option for expanded utility and fluorochrome options? Simple push...
型號:
時間: 2019 - 04 - 17
描述The 2018 Attune NxT Acoustic Focusing Cytometer has expanded functionalities to drive your research forward. Designed and developed to remove common barriers associated with flow cytometry, the evolutionary capabilities of the Attune NxT flow cytometer offer adaptable optical configuration options so you can get the most out of your multicolor analysis.? Free Attune NxT software with researcher-inspired upgrades? New green laser option for expanded utility and fluorochrome options? Simple push...
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