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2018 - 05 - 18
5月18日消息,哈佛大學的創業者Rejuvenate Bio已經開始測試為犬類延長壽命的方法,如果這項技術獲得成功,那么將在人類身上進行試驗。公司的合創者,63歲的George Church稱,如果在查理士王小獵犬身上進行的醫學測試成果的話,他將在自己身上進行測試。       查理士王小獵犬通常有一種心臟上的小疾病,導致半數物種在10歲左右時會因病死去。研究人員的研究已經表明,改變單一生物體的基因能夠使其壽命加倍,并且在蒼蠅身上取得了成功。這項研究的目的是觀察在保持物種年輕身體狀態的同時延長物種壽命會帶來什么樣的結果。Church教授被視作 “基因編輯”領域的一位先驅者,而且也正致力于借助史前DNA復活猛犸象的研究。他的返老還童實驗室將發表一份關于這項技術的報告,研究人員將對老齡化疾?。ū热缯f心臟病和糖尿病等)相關的兩種基因進行修改,從而延長嚙齒動物的壽命。麻省理工學院《技術評論》去年6月獲得的一份文件表明,該創業公司在塔夫茨陸軍獸醫學院對4只米格魯獵犬進行了測試。雖然文件中關于這次醫學實驗的過程透漏的很少,但是麻省理工學院的《技術評論》雜志推測,這一過程可能需要抑制一種充當“總開關”的蛋白質。Church教授稱:“我們已經在老鼠身上進行了一系列的實驗,而且我們正在犬類身上進行一些實驗,隨后我們將在人類身上進行這項技術的實驗。犬類不僅僅是接...
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2019 - 03 - 08
1 月 28 日,國際學術期刊 Circulation Research 在線發表了中國科學院上海營養與健康研究所宗耕課題組與哈佛大學公共衛生學院營養系合作的最新研究成果 “Associations of Monounsaturated Fatty Acids from Plant and Animal Sources with Total and Cause-Specific Mortality in Two US Prospective Cohort Studies”。該研究發現較高的植物來源單不飽和脂肪酸(MUFA-Ps)攝入量與較低的總死亡率相關,而動物來源單不飽和脂肪酸(MUFA-As)的攝入則與較高死亡率相關。另外,用植物來源單不飽和脂肪酸替代飽和脂肪酸(SFAs)、精加工的碳水化合物或反式脂肪可以顯著降低死亡風險。在全球范圍內,心血管疾?。–VD)和癌癥是造成過早死亡的最主要原因。目前,越來越多的研究表明采取健康的生活方式(如戒煙、增加體力活動和提高膳食質量等)能夠有效降低過早死亡的風險。多個國家的膳食指南均強調了膳食脂肪的質量對預防慢性疾病的重要性,尤其提倡植物油及其他植物來源的脂肪攝入。例如,膳食中的多不飽和脂肪酸(PUFAs)主要來自植物,而現有的研究表明 PUFAs 能夠降低心血管疾病風險和死亡率的關系。與之相比,飲食中的單不飽和脂肪酸只有一半來自植物油(尤其...
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2019 - 07 - 05
據新華社電 美國疾病控制和預防中心研究團隊發現,正在剛果(金)使用的兩種試驗性療法對抗擊當前的埃博拉疫情有效。7 月 9 日發表在英國《柳葉刀—傳染病》雜志上的研究顯示,在實驗室中,抗病毒藥物 Remdesivir,以及由三種抗體組成的抗埃博拉藥物 ZMapp 可阻斷新一輪埃博拉疫情的致病毒株在人類細胞中增長。確認抗病毒藥物有效的關鍵之一在于找到此次疫情的致病毒株。論文第一作者、美疾控中心微生物學家勞拉 · 麥克馬倫說,目前在剛果(金)試用的療法均針對以前疫情中獲取的埃博拉毒株,而埃博拉是一種核糖核酸(RNA)病毒,會不斷變異,因此確定現有療法是否對新毒株奏效至關重要。美疾控中心研究人員沒有當前在剛果(金)傳播的 “伊圖里” 毒株樣本,但他們從開源基因庫中獲得病毒序列數據,使用 “反向遺傳學” 技術重組了毒株。這項技術有助于研究人員更多了解新毒株在埃博拉家族樹中的位置,從而尋找更多潛在療法,并測試各類新療法的有效性,還可與未來的新毒株進行比對。研究中還發現,2014 年到 2016 年西非多國爆發埃博拉疫情期間開發的一種實驗室病毒診斷方法可用于診斷 “伊圖里” 毒株。(周舟)文章摘自:生物360
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產品名稱: K3 Plus酶標儀
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時間: 2019 - 05 - 23
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時間: 2019 - 04 - 22
描述The LIVE/DEAD? Fixable Green Dead Cell Stain Kit is used to determine the viability of cells prior to the fixation and permeabilization required for intracellular antibody staining or prior to elimination of biohazardous materials using formaldehyde fixation. This kit has been optimized and validated for use with a blue laser flow cytometer.? Stable—dyes are freeze dried in separate vials to maintain stability? Robust—staining pattern is the same before and after fixation? Bright signal—allows...
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時間: 2019 - 04 - 18
描述This product detects the externalization of phosphatidylserine in apoptotic cells using recombinant annexin V conjugated to green-fluorescent FITC dye and dead cells using propidium iodide (PI). Propidium iodide stains necrotic cells with red fluorescence. After treatment with both probes, apoptotic cells show green fluorescence, dead cells show red and green fluorescence, and live cells show little or no fluorescence.
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時間: 2019 - 04 - 18
描述SYTOX® Green nucleic acid stain is an excellent green-fluorescent nuclear and chromosome counterstain that is impermeant to live cells, making it a useful indicator of dead cells within a population.?  Impermeant to live cells?  Excitation/Emission: 504/523 nm?  Use with 488 Argon-ion laser?  Works with mammalian cells and both Gram-positive and Gram-negative bacteriaSimple Viability Determination SYTOX® Green allows quick determination of cell viability when usin...
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時間: 2019 - 04 - 18
描述Premo? FUCCI Cell Cycle Sensor is a fluorescent, two-color sensor of cell cycle progression and division in live cells. It allows accurate and sensitive cell cycle analysis of individual cells or a population of cells by fluorescence microscopy, flow cytometry, or high-content imaging.At 2 x 200 µL, this is a smaller pack size version (1/5 volume) of the popular full-size product and perfect for testing its performance in your system.The Premo? FUCCI Cell Cycle Sensor is delivered by high...
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時間: 2019 - 04 - 18
描述CountBright? absolute counting beads are a calibrated suspension of microspheres that are brightly fluorescent across a wide range of excitation and emission wavelengths (UV to 635 nm excitation and 385-800 nm emission). CountBright? absolute counting beads are mixed with the cell sample and assayed via flow cytometry. By comparing the ratio of bead events to cell events, absolute numbers of cells in the sample can be calculated. Because CountBright? beads are mixed in the test sample, absolut...
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時間: 2019 - 04 - 17
描述CellTrace? CFSE Cell Proliferation Kit is used for in vitro and in vivo labeling of cells to trace multiple generations using dye dilution by flow cytometry.? Superior performance—bright, single-peak staining enables visualization of multiple generations? Long-term signal stability—well-retained in cells for several days post stain? Non-toxic—staining does not adversely effect cell health? Simple, robust staining protocolView a selection guide for all CellTrace? Cell Proliferation Kits fo...
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時間: 2019 - 04 - 17
描述CellTrace? CFSE 細胞增殖試劑盒 (CellTrace? CFSE Cell Proliferation Kit) 以方便的一次性瓶裝形式提供用途廣泛,穩定性高的細胞示蹤劑。 羧基熒光素二醋酸鹽琥珀酰亞胺酯,常稱為 CFSE,可被動擴散進入細胞。 這種試劑沒有顏色和熒光,直至細胞內的酯酶去除其醋酸鹽基團,產生能發出明亮熒光的羧基熒光素琥珀酰亞胺酯。 琥珀酰亞胺酯與細胞內氨基反應,形成穩定且能用醛固定劑固定的熒光偶聯物。 此試劑盒包含十份一次性瓶裝的 CFSE,因此進行小規模實驗時無需制備過量的易變質 CFSE 儲存液。 此試劑盒還包括高質量的 DMSO(二甲基亞砜)和詳細的實驗方案。For Research Use Only. Not for use in diagnostic procedures.圖表Suppressive capacity of isolated Treg cells.Suppressive capacity of isolated Treg cells. (A) CD4+ CD25–cells were stained with Ca...
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時間: 2019 - 04 - 17
描述The Click-iT® EdU Pacific Blue? Flow Cytometry Assay Kit provides a simplified, more robust assay for analyzing DNA replication in proliferating cells as compared to traditional BrdU methods. Newly synthesized DNA is analyzed using the 405 nm laser of the flow cytometer.? Accurate—superior results compared to BrdU assays? Fast—results in as little as 90 minutes? Economical—more assays per kitView selection guide for all Click-iT? EdU and Click-iT? Plus EdU assays for flow c...
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時間: 2019 - 04 - 17
描述The 2018 Attune NxT Acoustic Focusing Cytometer has expanded functionalities to drive your research forward. Designed and developed to remove common barriers associated with flow cytometry, the evolutionary capabilities of the Attune NxT flow cytometer offer adaptable optical configuration options so you can get the most out of your multicolor analysis.? Free Attune NxT software with researcher-inspired upgrades? New green laser option for expanded utility and fluorochrome options? Simple push...
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時間: 2019 - 04 - 17
描述The 2018 Attune NxT Acoustic Focusing Cytometer has expanded functionalities to drive your research forward. Designed and developed to remove common barriers associated with flow cytometry, the evolutionary capabilities of the Attune NxT flow cytometer offer adaptable optical configuration options so you can get the most out of your multicolor analysis.? Free Attune NxT software with researcher-inspired upgrades? New green laser option for expanded utility and fluorochrome options? Simple push...
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時間: 2019 - 04 - 17
描述The 2018 Attune NxT Acoustic Focusing Cytometer has expanded functionalities to drive your research forward. Designed and developed to remove common barriers associated with flow cytometry, the evolutionary capabilities of the Attune NxT flow cytometer offer adaptable optical configuration options so you can get the most out of your multicolor analysis.? Free Attune NxT software with researcher-inspired upgrades? New green laser option for expanded utility and fluorochrome options? Simple push...
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